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Oxidative stress in hypertension
Sáez, Guillermo T; Redon, Josep.
  • Sáez, Guillermo T; University of Valencia. Medical School. Department of Biochemistry and Molecular Biology. Valencia. ES
  • Redon, Josep; University of Valencia. Medical School. Department of Biochemistry and Molecular Biology. Valencia. ES
Rev. bras. hipertens ; 10(4): 239-249, out.-dez. 2003. ilus, tab
Article in English | LILACS | ID: lil-360846
ABSTRACT
Reactive oxygen species interfere with the mechanisms controlling BP and play an important role in the development of hypertension and vascular damage. Oxidative stress is increased in hypertensive subjects even in cells other than those present in the vascular wall. This increased oxidative stress, not related to BP values, is accompanied by a reduction in the most important antioxidant mechanisms and by a accumulation of reactive oxygen species by product not only from lipid peroxidation but also from oxidized genomic and mitochondrial DNA. To better understand the clinical significance of oxidative stress in hypertension, it is necessary to explore whether the reduction in antioxidant mechanisms is the cause or the consequence of oxidative stress.
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Index: LILACS (Americas) Main subject: Oxidative Stress / Arterial Pressure / Hypertension Limits: Animals / Humans Language: English Journal: Rev. bras. hipertens Journal subject: Cardiology Year: 2003 Type: Article Affiliation country: Spain Institution/Affiliation country: University of Valencia/ES

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Index: LILACS (Americas) Main subject: Oxidative Stress / Arterial Pressure / Hypertension Limits: Animals / Humans Language: English Journal: Rev. bras. hipertens Journal subject: Cardiology Year: 2003 Type: Article Affiliation country: Spain Institution/Affiliation country: University of Valencia/ES