Uso de metotrexato en pacientes con lupus eritematoso sistÚmico / Methotrexate use in patients with systemic lupus erythematosus
Rev. méd. Chile
;
132(2): 195-201, feb. 2004. tab, graf
Article
in Spanish
| LILACS
| ID: lil-361496
RESUMO
Background:
In the past ten years, methotrexate (MTX) has appeared as an alternative for the treatment of systemic lupus erythematosus (SLE).Aim:
To evaluate the use of MTX and the results of treatment in a group of patients with SLE. Patients andMethods:
Retrospective review of 426 files of patients with SLE. Of these, all patients treated with MTX were selected. A review protocol was designed, stating sex, age, time of disease evolution, previous treatment, MTX prescription, doses, effectiveness and side effects.Results:
Seven patients were selected. All were women, with an age range of 26 to 62 years old and with 5 to 34 years of disease evolution. Previous treatment with non steroidal anti-inflammatory drugs, steroids, hydroxychloroquine and azathioprine ranged from 6 to 631 months (average=147.3). Persistent joint and/or skin manifestations were the main cause for the use of MTX. The dose ranged from 7.5 to 15 mg and the treatment lapse from 6 to 106 months. It was effective in all patients, allowing a reduction in prednisone doses. Two patients experienced a rise in serum transaminases and one had gastric intolerance, that required treatment discontinuation.Conclusions:
MTX is rarely used in SLE. Its main prescription and effectiveness is in joint and skin manifestations, allowing to decrease steroid doses. However, side effects are frequent.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Methotrexate
/
Lupus Erythematosus, Systemic
Type of study:
Practice guideline
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2004
Type:
Article
Affiliation country:
Portugal
Institution/Affiliation country:
Hospital San Juan de Dios/CL
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