Recurrence risks for isolated cases of nonsyndromic deafness
Genet. mol. biol
;
27(2): 154-161, Jun. 2004. tab
Article
in English
| LILACS
| ID: lil-362895
RESUMO
We present, in this paper, general formulae developed so as to permit the calculation of the recurrence risks for isolated cases of nonsyndromic deafness in the offspring of nonconsanguineous and consanguineous couples. We included, in all analyzed situations, the following factors (a) a generic degree of parental consanguinity; (b) a variable proportion of environmental (non-genetic) cases of the defect, so that the formulae can be easily applied to populations with any epidemiological profile; (c) a variable number of normal sibs of the propositus. Besides presenting the logic and the detailed derivation of all original formulae, we present tables for immediate use, with the numerical values of the recurrence risks as a function of the variables mentioned above.
Full text:
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Index:
LILACS (Americas)
Main subject:
Deafness
Type of study:
Etiology study
/
Risk factors
Limits:
Child
/
Humans
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2004
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Maringá/BR
/
Universidade de São Paulo/BR
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