Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility

ABSTRACT

Insulin-like growth factor II (IGF2) has been shown to play a role in abnormal cell growth and carcinogenesis. We investigated if the IGF2 gene Apa I polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with moderate/severe endometriosis and 103 controls. The genotype frequencies did not differ statistically between the endometriosis (aa = 25.4, ab = 57.4, bb = 17.2 percent) and control (aa = 20.8 ab = 52.8, bb = 26.4 percent) groups. The allele frequencies did not differ either: a = 54.1, b = 45.9 percent among women with endometriosis and a = 47.2, b = 52.8 percent in the control group. Therefore, no indication was found for an association of this polymorphism with endometriosis susceptibility.