Significant and transitory control of lesions development in mice immunized with a genomic library of Leishmania amazonensis
Rev. patol. trop
;
31(2): 245-248, jul.-dez. 2002. graf
Article
in English
| LILACS
| ID: lil-363181
ABSTRACT
DNA from a genomic library of Leishmania amazonensis and from pcDNA3 plasmid were used to immunize BALB/c mice. Three immunizations at two weeks intervals were done, with 50µg/0.1ml of DNA. A control group was also injected with the same volume of saline solution. Afterward, all mice were challenged with infective promastigotes of the parasite, and the development of lesions was followed during 16 weeks by dorsoventral measures of the footpad. Mice previously immunized with the genomic library were capable of controlling lesions at a significant level, with major significance between 9 and 13 weeks post challenge.
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Index:
LILACS (Americas)
Main subject:
Genomic Library
/
Vaccines, DNA
/
Leishmania
Limits:
Humans
Language:
English
Journal:
Rev. patol. trop
Journal subject:
Tropical Medicine
/
Pathology
Year:
2002
Type:
Article
Affiliation country:
Cuba
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