Oral Candida flora from Brazilian human immunodeficiency virus-infected patients in the highly active antiretroviral therapy era
Mem. Inst. Oswaldo Cruz
;
99(4): 425-431, Jun. 2004. tab
Article
in English
| LILACS
| ID: lil-363862
RESUMO
One of the main opportunistic fungal infections amongst immunocompromised individuals is oral candidosis, which has been found in up to 90 percent of human immunodeficiency virus (HIV)-infected patients. This study employed yeasts isolated from the saliva and oral cavities of 114 HIV-infected patients living in Campinas, São Paulo. Of the isolates, 57.8 percent were identified as Candida albicans and 42.1 percent as non-C. albicans. The latter isolates were subsequently identified as C. krusei (7.5 percent), C. lusitaniae (5.2 percent), C. tropicalis (4.6 percent), C. parapsilosis (4.6 percent), C. glabrata (2.8 percent), C. kefyr (1.7 percent), C. guilliermondii (1.7 percent), C. intermedia (1.1 percent), C. norvegensis (0.5 percent), and Rhodotorula rubra (1.7 percent). Susceptibility of the isolates to amphotericin B, fluconazole, miconazole, and itraconazole was also determined by a microdilution method adopted by the National Committee for Clinical Laboratory Standards. The isolates demonstrated various susceptibilities to the antifungal agents. In particular 29 C. albicans and 13 non-C. albicans isolates showed low susceptibility to FLCZ (> 64 æg/ml). This study revealed huge diversity of Candida species, in particular the increasing emergence of non-C. albicans associated with the oral flora of HIV-infected patients.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Candida
/
Candidiasis, Oral
/
HIV Infections
/
AIDS-Related Opportunistic Infections
/
Antiretroviral Therapy, Highly Active
/
Antifungal Agents
Type of study:
Practice guideline
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2004
Type:
Article
/
Project document
Affiliation country:
Brazil
/
Japan
Institution/Affiliation country:
Chiba University/JP
/
Faculdade de Odontologia de Piracicaba/BR
/
Unicamp/BR
Similar
MEDLINE
...
LILACS
LIS