Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar / DNA content and survival in subserous gallbladder carcinoma
Rev. méd. Chile
;
132(7): 794-800, jul. 2004. tab, graf
Article
in Spanish
| LILACS
| ID: lil-366578
ABSTRACT
Background:
The clinical and morphological characterization of the subserous gallbladder carcinomas is controversial.Aim:
To study the prognostic importance of DNA content of subserous gallbladder carcinoma. Material andmethods:
We studied 104 females aged 60±12 years old and 16 men aged 70±13 years old. In all of them diagnosis was established after mapping of cholecystectomy sample and had a complete clinical follow up. DNA content was measured by flow cytometry.Results:
All tumors were adenocarcinoma, and only 16 percent were well differentiated. Aneuploidy was observed in 29 cases (26 perceeeent) with DNA index fluctuating between 1.1 and 1.8. Lymphatic vessel tumor involvement was present in 16 of 22 cases with aneuploidy and in 22 of 46 diploid tumors (p= 0.05). Eighty nine percent of aneuploid tumors were detected macroscopically and 11 percent were unapparent. Five years survival was non significantly better among patients with diploid tumors than in patients with aneuploid tumors (45 and 28 percent, respectively, p= 0.2). The histological differentiation was the only variable significantly associated with survival.Conclusions:
Aneuploidy is present in 26 percent of subserous gallbladder carcinoma. It is not related with any of the morphological or clinical variables studied in this series of patients.
Full text:
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Index:
LILACS (Americas)
Main subject:
DNA, Neoplasm
/
Gallbladder Neoplasms
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2004
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
/
Universidad de la Frontera/CL
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