Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño case-only / Gene-gene and gene-environment interactions as modifier factors of prostatic cancer risk: a case-only design study
Rev. méd. Chile
;
132(8): 961-970, ago. 2004. tab
Article
in Spanish
| LILACS
| ID: lil-384192
ABSTRACT
Background: The role of susceptibility low penetrance genes and environmental factors in the etiology of prostate cancer (PCa) is unclear, but may involve in some cases multiple alleles at multiple loci. Aim: To evaluate the association of gene-gene and gene-environment interactions with PCa. Patients and methods: One hundred three subjects with biopsy proven PCa were studied, using a case-only design. All were interrogated about smoking habits. Polymorphisms for Glutathione-S-transferase (GST) and Cytochrome P4501A1 (CYP1A1), were measured in DNA extracted from peripheral Iymphocytes, using a restriction fragment length polymorphism analysis. Results: Our findings suggest that gene-gene interactions between GSTT1 and CYP1A1 high risk genotypes were positive modifiers and had a high predictive value for the presence of PCa, compared with non-susceptibility genotypes. The interaction between susceptibility genotypes and smoking did not modify the risk for PCa. Conclusions: Gene-gene interactions may play a role modulating the susceptibility to PCa in a proportion of affected individuals (Rev Méd Chile 2004; 132: 961-66).
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Genetic Predisposition to Disease
/
Environment
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2004
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Corporación Nacional del Cáncer/CL
/
Universidad de Chile/CL
Similar
MEDLINE
...
LILACS
LIS