Cell membrane fatty acid composition differs between normal and malignant cell lines
P. R. health sci. j
;
23(2): 103-106, Jun. 2004.
Article
in English
| LILACS
| ID: lil-390795
RESUMO
Twenty-eight fatty acids (C80 to C24l n-9) were measured by gas chromatography in four normal cell lines (C3H / 10T1 / 2, CCD-18Co, CCD-25SK and CCD-37Lu) and seven cancer cell lines (C-41, Caov-3, LS-180, PC-3, SK-MEL-28, SK-MES-1 and U-87 MG). Results show differences in the content and proportions of fatty acids when comparing cancer cell lines with their normal counterparts. Cancer cell lines showed lower C20 4 n-6, C241 n-9, polyunsaturated fatty acids (PUFA's) and ratios of C204 n-6 to C205 n-3 and C160 to C181 n-9 and stearic to oleic (SA/OA) than their normal counterparts. All cancer cell lines had SA/OA ratios lower than 7.0 while normal cell lines had ratios greater than 0.7 (p<0.05). In addition, the ratios of total saturated fatty acids (SFA) to PUFA'S and the concentration of C181 n-9, C182 n-6, C205 n-3 were higher in cancer cell lines as compared to normal cell lines. A positive correlation was detected between C160 and longer SFA'S (r = +0.511, p<0.05) in normal cell lines whereas a negative correlation (r=0.608, p<0.05) was obtained for malignant cell lines. Moreover, cancerous cell lines exhibited a particular desaturation defect and an abnormal incorporation of C182 n-6 and C20-4 n-6 fatty acids
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Index:
LILACS (Americas)
Main subject:
Cell Membrane
/
Cell Line, Tumor
/
Fatty Acids
Limits:
Animals
/
Humans
Language:
English
Journal:
P. R. health sci. j
Journal subject:
Medicine
Year:
2004
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Center for the Improvement of Human Functioning International/US
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