Your browser doesn't support javascript.
loading
Analysis of the molecular association of rifampicin with hydroxypropyl-ß-cyclodextrin
Ferreira, Denise Alves; Ferreira, Antonio Gilberto; Vizzotto, Lucinéia; Federman Neto, Alberto; Oliveira, Anselmo Gomes de.
  • Ferreira, Denise Alves; Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Ciências Farmacêuticas. Departamento de Fármacos e Medicamentos. BR
  • Ferreira, Antonio Gilberto; Universidade Federal de São Carlos. Departamento de Química. Laboratório de RMN. BR
  • Vizzotto, Lucinéia; Universidade Federal de São Carlos. Departamento de Química. Laboratório de RMN. BR
  • Federman Neto, Alberto; Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Laboratório de Química. BR
  • Oliveira, Anselmo Gomes de; Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Ciências Farmacêuticas. Departamento de Fármacos e Medicamentos. BR
RBCF, Rev. bras. ciênc. farm. (Impr.) ; 40(1): 43-51, jan.-mar. 2004. ilus, tab, graf
Article in English | LILACS | ID: lil-391011
ABSTRACT
Inclusion complexes of rifampicin (RP) were prepared with hydroxypropyl-ß-cyclodextrin (HPßCD). The aqueous solubility of RP increased linearly with cyclodextrin concentration in all range of the solubility diagram. The data was analyzed using the framework of Higuchi and Connors. The stability constant (K) values for RP/HPßCD complex at pH 6.9 were 18 and 120-125 M-1 for ionic strength 0.01 and 0.18M, respectively. The analysis of the chemical shift data of 1H and 15N for free RP and RP/HPßCD inclusion complex reveal that only peaks of the side chain related to the piperazine ring of RP change substantially, probably due to interaction of this region of RP molecule with the hydrophobic core of HPßCD...
Subject(s)
Fulltext
Print
XML
Search on Google
Full text: Available Index: LILACS (Americas) Main subject: Rifampin / Models, Molecular / Cyclodextrins Type of study: Risk factors Language: English Journal: RBCF, Rev. bras. ciênc. farm. (Impr.) Journal subject: Biochemistry / Pharmacy / Pharmacology Year: 2004 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista Júlio de Mesquita Filho/BR / Universidade Federal de São Carlos/BR / Universidade de São Paulo/BR

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
Search on Google
Full text: Available Index: LILACS (Americas) Main subject: Rifampin / Models, Molecular / Cyclodextrins Type of study: Risk factors Language: English Journal: RBCF, Rev. bras. ciênc. farm. (Impr.) Journal subject: Biochemistry / Pharmacy / Pharmacology Year: 2004 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista Júlio de Mesquita Filho/BR / Universidade Federal de São Carlos/BR / Universidade de São Paulo/BR