Cyclophosphamide identification in wipe test by GC-MS and solid phase extraction
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
40(1): 67-73, jan.-mar. 2004. tab, graf
Article
in English
| LILACS
| ID: lil-391014
RESUMO
In this study cyclophosphamide was quantified after adapting a prior analytical method using gas chromatography-mass spectrometry after solid phase purification and derivatization with trifluoroacetic anhydride. The analyte was measured by analysis in wipe test from infusion bags, which may be contaminated by contact with the gloves used during preparation of the drugs. Surface of bag contaminated may be an important source of contamination for workers in the others chemoterapy handling areas, such as administration rooms. This drug, in fact, is one of the most frequently used alkylating antineoplastic agents for different types of tumors and it is furthermore classified as a human carcinogen by IARC...
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pharmaceutical Preparations
/
Occupational Exposure
/
Cyclophosphamide
Type of study:
Diagnostic study
Language:
English
Journal:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Journal subject:
Biochemistry
/
Pharmacy
/
Pharmacology
Year:
2004
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
/
Università degli Studi di Brescia/BR
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