Lanreotide and octreotide complexed with technetium-99m: labeling, stability and biodistribution studies
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
40(1): 101-110, jan.-mar. 2004. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-391018
ABSTRACT
Lanreotide and Octreotide are cyclic octapeptide analogues of somatostatin that were labeled with the radioisotope Technetium-99m for use in diagnostic nuclear medicine. The peptides were processed in a tartrate/phthalate buffer solution containing reducing agent. The purpose of this investigation was to optimize direct labeling by varying some parameters, and to evaluate radiochemical stability and biodistribution in animals. The marked peptides were obtained with high labeling efficiency and no need for subsequent purification. best radiolabeling results corresponded to a molar ratio of SnCl2.H2O/peptide of 4.5. `ANTPOT. 99mTc'-peptides were radiochemically stable for 6 hours...
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Peptides
/
Octreotide
/
Technetium
/
Nuclear Medicine
Language:
English
Journal:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Journal subject:
Biochemistry
/
Pharmacy
/
Pharmacology
Year:
2004
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto de Pesquisas Energéticas e Nucleares/BR
/
Universidade Federal de São Paulo/BR
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