Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
Genet. mol. biol
;
27(4): 496-499, Dec. 2004. ilus, tab
Article
in English
| LILACS
| ID: lil-391219
ABSTRACT
The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67 percent) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33 percent) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.
Full text:
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Index:
LILACS (Americas)
Main subject:
Papillomaviridae
/
Carcinoma, Squamous Cell
/
Uterine Cervical Neoplasms
Type of study:
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2004
Type:
Article
Affiliation country:
Brazil
/
Italy
Institution/Affiliation country:
Hospital Maternidade Leonor Mendes de Barros/BR
/
Istituto Superiore di Sanità/IT
/
Universidade Estadual de Campinas/BR
/
Universidade Federal de São Paulo/BR
/
Universidade de São Paulo/BR
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