Immunogenicity of a 23-valent pneumococcal polysaccharide vaccine in Brazilian elderly
Braz. j. med. biol. res
;
38(2): 251-260, fev. 2005. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-393656
ABSTRACT
Serum antibodies specific for the capsular polysaccharides of Streptococcus pneumoniae provide protection against invasive pneumococcal infection. In Brazil, this vaccine has been used for people over 65 years with clinical risk to develop pneumococcal infection since 1999. We evaluated the immune response of 102 elderly subjects (75.5 percent females and 24.5 percent males) with a mean age of 71 years, and 19 young healthy adults (63.2 percent females and 36.8 percent males) with a mean age of 27 years. The elderly study group consisted of outpatients who received follow-up care in the Geriatric Department of General Hospital, Faculty of Medicine, University of São Paulo. None had acute illness at the time of vaccination. Both groups were immunized with one intra-deltoid injection with 0.5 ml of a 23-valent pneumococcal polysaccharide vaccine. The total IgG specific antibody concentrations to capsular polysaccharides 1, 3, 5, 6B, 8, and 14 were determined against pre- and 1-month post-vaccination sera. All samples were analyzed according to the second-generation pneumococcal polysaccharide ELISA protocol. We observed that the pneumococcal polysaccharide vaccine evoked consistent antibody increase for serotypes 1, 5, 6B, 8, and 14 (geometric mean concentration increase of 2.46 in the elderly and 2.84 in the young adults). Otherwise, we observed no increase in antibody concentration for serotype 3 in both groups.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pneumococcal Infections
/
Streptococcus pneumoniae
/
Pneumococcal Vaccines
Type of study:
Practice guideline
/
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2005
Type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
/
Instituto Adolfo Lutz/BR
/
Instituto Butantan/BR
/
Organização Panamericana de Saúde/US
/
Universidade de São Paulo/BR
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