Glucocorticoid-remediable aldosteronism
Arq. bras. endocrinol. metab
;
48(5): 682-686, out. 2004. ilus, tab
Article
in English
| LILACS
| ID: lil-393724
RESUMO
Glucocorticoid-remediable aldosteronism (GRA) is a monogenic form of human hypertension that predisposes to cerebral hemorrhage. As a result of a chimeric gene duplication, aldosterone is ectopically synthesized in the cortisol-secreting zona fasciculata of the adrenal gland under the control of adrenocorticotropin (ACTH). Hypertension frequently has its onset during childhood and is usually refractory to standard anti-hypertensives such as ACE inhibitors and beta-blockers. Hypokalemia can develop in those treated with a potassium-wasting diuretic, but random potassium levels are usually normal. Diagnosis has been facilitated by the availability of a genetic test. Suppression of ACTH release with exogenous dexamethasone is a useful diagnostic and therapeutic strategy. Treatment with the mineralocorticoid receptor antagonists spironolactone and epleronone is also efficacious. The diagnosis of GRA facilitates directed therapies and screening of at-risk individuals and kindreds.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Glucocorticoids
/
Hyperaldosteronism
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Arq. bras. endocrinol. metab
Journal subject:
Endocrinology
/
Metabolism
Year:
2004
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Brigham & Women's Hospital/US
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