Molecular pharmacology of chemo-resistant leishmania
Arch. venez. farmacol. ter
;
22(1): 19-24, 2003. graf
Article
in English
| LILACS
| ID: lil-395991
RESUMO
Infectious diseases leishmaniosis among them, constitute a leading cause of death world wide, especially in the developing world, where they remain as an important cause of concern and has become a serious problem because of the everyday enhanced risk of co infection with HIV and the increasing frequency of resistance development of the parasites to the drug agents. Emergence of drug resistance is usually associated with changes in the expression of an specific membrane P-glycoprotein, but also includes physiological responses with high complexity. In the present review we summarize results which emphasize that the comprehesion of the molecular pharmacology of drug-resistant phenotype must include, as a way for identifying new strategies for the control of the disease, the understanding of the multiple biochemical and functional parasite mechanisms involved
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Infections
/
Leishmania
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Venezuela
Language:
English
Journal:
Arch. venez. farmacol. ter
Journal subject:
Pharmacology
/
Therapeutics
Year:
2003
Type:
Article
Affiliation country:
Venezuela
Institution/Affiliation country:
Universidad Central de Venezuela/VE
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