Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals
Mem. Inst. Oswaldo Cruz
;
100(1): 85-89, Feb. 2005. ilus
Article
in English
| LILACS
| ID: lil-398122
RESUMO
Anti-human immunodeficiency virus type 1 (HIV-1) "binding antibodies" (antibodies capable of binding to synthetic peptides or proteins) occur throughout HIV-1 infection, are high-titered and highly cross-reactive, as confirmed in this study by analyzing plasma from B and F genotype HIV-1 infected individuals. Plasma from individuals infected with clade F HIV-1 displayed the most frequent cross-reactivity, in high titers, while Bbr plasma showed much higher specificity. Similarly, neutralization of a reference HIV-1 isolate (HIV-1 MN) was more frequently observed by plasma from F than B genotype infected individuals. No significant difference was seen in neutralization susceptibility of primary B, Bbr or F clade HIV-1 by plasma from individuals infected with the classical B (GPGR) or F HIV-1, but Bbr (GWGR) plasma were less likely to neutralize the F genotype primary HIV-1 isolates. The data indicate that both B and F genotype derived vaccines would be equally effective against B and F HIV-1 infection, with a slightly more probable effectiveness for F than B genotype. Although the Bbr variant appears to induce a much more specific humoral immune response, the susceptibility in neutralizing the Brazilian HIV-1 B genotype Bbr variant is similar to that observed with the classical B genotype HIV-1.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Peptide Fragments
/
HIV Antibodies
/
HIV Antigens
/
HIV-1
/
Antibody Specificity
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2005
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Centro de Informações Científicas e Tecnológicas-Fiocruz/BR
/
Instituto Oswaldo Cruz-Fiocruz/BR
/
Instituto de Pesquisa Evandro Chagas-Fiocruz/BR
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