Obesity influences propranolol pharmacokinetics in patients undergoing coronary artery bypass grafting employing cardiopulmonary bypass

ABSTRACT

Propranolol plasma levels and kinetic disposition may be altered by hypoyhermic cardiopulmonary bypass (CPB-H). We investigated the potential influence of obesity on propranolol pharmacokinetics in patients undergoing coronary artery bypass grafting employing CPB-H. Fifteen patients, receiving propranolol perorally pre-(10-40 mg, 2-3 times a day) and post-operatively (10 mg, once a day) were distributed in two groups, based on body mass index (BMI), in obese (n=9, BMI mean 29,4 kg/m²) and non-obese (n=6 BMI mean 24.8 kg/m²). A serial of blood samples was collected at the pre- and post-operative periods at time dosing interval (`tau´) propranolol plasma levels were measured one day before and after surgery using a high performance liquid chromatographic procedure described previously...