GATM, the human ortholog of the mouse imprinted Gatm gene, escapes genomic imprinting in placenta
Genet. mol. biol
;
28(1): 44-45, Jan.-Mar. 2005.
Article
in English
| LILACS
| ID: lil-399614
ABSTRACT
The GATM gene encodes L-arginine:glycine amidinotransferase, which catalyzes the conversion of L-arginine into guanidinoacetate, the rate-limiting step in the synthesis of creatine. Since, deficiencies in creatine synthesis and transport lead to certain forms of mental retardation in human, the human GATM gene appears to be involved in brain development. Recently it has been demonstrated that the mouse Gatm is expressed during development and is imprinted with maternal expression in the placenta and yolk sac, but not in embryonic tissues. We investigated the imprinting status of the human GATM by analyzing its expression in four human placentas. GATM was biallelically expressed, thus suggesting that this gene escapes genomic imprinting in placentas, differently from what has been reported in mouse extra-embryonic tissues.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Genomic Imprinting
/
Amidinotransferases
/
Glycine
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2005
Type:
Article
/
Project document
Affiliation country:
Japan
Institution/Affiliation country:
Asahikawa Medical College/JP
/
Ryukyu University School of Medicine/JP
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