Your browser doesn't support javascript.
loading
Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced chromosomal aberrations in CHO cells
Antunes, Lusânia Maria Greggi; Araújo, Maria Cristina Paiva; Dias, Francisca da Luz; Takahashi, Catarina Satie.
  • Antunes, Lusânia Maria Greggi; Faculdade de Medicina do Triângulo Mineiro. Departamento de Ciências Biológicas. Uberaba. BR
  • Araújo, Maria Cristina Paiva; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto. BR
  • Dias, Francisca da Luz; Faculdade de Medicina do Triângulo Mineiro. Departamento de Ciências Biológicas. Uberaba. BR
  • Takahashi, Catarina Satie; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto. BR
Genet. mol. biol ; 28(1): 161-164, Jan.-Mar. 2005. tab
Article in English | LILACS | ID: lil-399634
ABSTRACT
The effects of H2O2, Fe2+ and Fe3+ on curcumin-induced clastogenicity were evaluated in CHO cells. Curcumin combined with H2O2 did not increase the chromosomal aberrations more than expected based on a simple additive effect. In contrast, the combination of curcumin-Fe significantly decreased the total number of chromosomal aberrations and the number of abnormal metaphases. The clastogenicity of curcumin may be related to its pro-oxidant properties and its ability to generate free radicals.
Subject(s)
Fulltext
Print
XML
Search on Google
Full text: Available Index: LILACS (Americas) Main subject: DNA Damage / CHO Cells / Curcumin Limits: Animals Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina do Triângulo Mineiro/BR / Universidade de São Paulo/BR

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
Search on Google
Full text: Available Index: LILACS (Americas) Main subject: DNA Damage / CHO Cells / Curcumin Limits: Animals Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina do Triângulo Mineiro/BR / Universidade de São Paulo/BR