Nitric oxide: a major determinant of mast cell phenotype and function
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 11-14, Mar. 2005. tab
Article
in English
| LILACS
| ID: lil-402169
RESUMO
Mast cells (MC) are important in the numerous physiological processes of homeostasis and disease. Most notably, MC are critical effectors in the development and exacerbation of allergic disorders. Nitric oxide (NO) is a diatomic radical produced by nitric oxide synthase (NOS), and has pluripotent cell signaling and cytotoxic properties. NO can influence many MC functions. Recent evidence shows the source of this NO can be from the mast cell itself. Governing the production of this endogenous NO, through alterations in the expression of tetrahydrobiopterin (BH4), a NOS cofactor, has stabilizing effects on MC degranulation. Furthermore, NO regulates the synthesis and secretion of de novo generated mediators, including leukotrienes and chemokines. These novel observations add to the growing body of knowledge surrounding the role of NO in the MC.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Mast Cells
/
Nitric Oxide
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2005
Type:
Article
Affiliation country:
Canada
/
United States
Institution/Affiliation country:
Institute for Systems Biology/US
/
University of Alberta/CA
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