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Nitric oxide synthase activity and endogenous inhibitors in rats recovered from allergic encephalomyelitis
Teixeira, S. A; Varriano, A. A; Dias, A. A; Martins Porto, R; Muscará, M. N.
  • Teixeira, S. A; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. São Paulo. BR
  • Varriano, A. A; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. São Paulo. BR
  • Dias, A. A; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. São Paulo. BR
  • Martins Porto, R; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. São Paulo. BR
  • Muscará, M. N; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. São Paulo. BR
Mem. Inst. Oswaldo Cruz ; 100(supl.1): 25-27, Mar. 2005. ilus, tab
Article in English | LILACS | ID: lil-402172
ABSTRACT
We have previously reported that in comparison with normal rats, the presence of experimental allergic encephalomyelitis (EAE) leads to decreased endogenous inhibitory activity (EIA) of Ca2+-dependent nitric oxide synthase (NOS) in both brain and serum, and increased expression of protein 3-nitrotyrosine (NT) in brain. In this work we show that animals recovered from the clinical signs of EAE are not different from controls in terms of either brain NOS activity, EIA of NOS, or NT expression. These results suggest that parallel to the reversal of the disease symptoms, a normalization of the production of nitric oxide and related species occurs.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Brain / Encephalomyelitis, Autoimmune, Experimental / Nitric Oxide Synthase Type III / Nitric Oxide Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Brain / Encephalomyelitis, Autoimmune, Experimental / Nitric Oxide Synthase Type III / Nitric Oxide Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR