Mechanisms of eosinophil cytokine release
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 73-81, Mar. 2005. ilus
Article
in English
| LILACS
| ID: lil-402179
RESUMO
Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine mediator. IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow eosinophils with distinct abilities in innate and acquired immunity.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cell Degranulation
/
Cytokines
/
Eosinophils
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2005
Type:
Article
/
Project document
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Harvard Medical School/US
/
Instituto Oswaldo Cruz/BR
Similar
MEDLINE
...
LILACS
LIS