Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 83-91, Mar. 2005. ilus, graf
Article
in English
| LILACS
| ID: lil-402180
RESUMO
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAF. This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A2 that also degrades a family of PAF-like oxidized phospholipids with short sn-2 residues. Biochemical and enzymological evaluations revealed that at least three types of PAF-AH exist in mammals, namely the intracellular types I and II and a plasma type. Many observations indicate that plasma PAF AH terminates signals by PAF and oxidized PAF-like lipids and thereby regulates inflammatory responses. In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Blood Platelets
/
Platelet Activating Factor
/
Inflammation
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2005
Type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Instituto Oswaldo Cruz/BR
/
University of Utah/US
Similar
MEDLINE
...
LILACS
LIS