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Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin
Dale, Camila Squarzoni; Pagano, Rosana de Lima; Rioli, Vanessa.
  • Dale, Camila Squarzoni; Instituto Butantan. Laboratório de Fisiopatologia. São Paulo. BR
  • Pagano, Rosana de Lima; Instituto Butantan. Laboratório de Fisiopatologia. São Paulo. BR
  • Rioli, Vanessa; Instituto Butantan. Centro de Toxicologia Aplicada. São Paulo. BR
Mem. Inst. Oswaldo Cruz ; 100(supl.1): 105-106, Mar. 2005. ilus
Article in English | LILACS, SES-SP | ID: lil-402183
ABSTRACT
Hemopressin (PVNFKFLSH), a novel bioactive peptide derived from the alpha1-chain of hemoglobin, was originally isolated from rat brain homogenates. Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE). Hemopressin also exerts an antinociceptive action in experimental inflammatory hyperalgesia induced by carrageenin or bradykinin via a mechanism that is independent of opioids. These findings suggest that this peptide may have important regulatory physiological actions in vivo.
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Full text: Available Index: LILACS (Americas) Main subject: Peptide Fragments / Hemoglobins / Hyperalgesia / Analgesics / Hypotension Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Year: 2005 Type: Article Institution/Affiliation country: Instituto Butantan/BR

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Full text: Available Index: LILACS (Americas) Main subject: Peptide Fragments / Hemoglobins / Hyperalgesia / Analgesics / Hypotension Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Year: 2005 Type: Article Institution/Affiliation country: Instituto Butantan/BR