Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 177-180, Mar. 2005. ilus
Article
in English
| LILACS
| ID: lil-402196
RESUMO
Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Periodontitis
/
Receptors, Proteinase-Activated
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2005
Type:
Article
Affiliation country:
Brazil
/
Canada
Institution/Affiliation country:
Alberta Heritage Foundation for Medical Research Scholar/CA
/
Universidade Estadual de São Paulo/BR
/
University of Calgary/CA
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