Resistencia primaria a terapia antirretroviral en pacientes con infección por VIH/SIDA en Chile / Primary resistance to antiretroviral therapy in patients with HIV/AIDS in Chile
Rev. méd. Chile
;
133(3): 295-301, mar. 2005. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-404885
ABSTRACT
Background:
Resistance to antiretroviral therapy is a determining factor for therapeutic failure in HIV/AIDS. The prevalence of primary resistance (i.e. in those patients that have not received treatment) varies in different parts of the world.Aim:
To study the prevalence of primary resistance to antiretroviral drugs in patients living in Northern Santiago. Patients andmethods:
Viral load, lymphocyte subpopulations by flow cytometry and genotypic resistance testing were assessed in blood samples from 60 HIV-1 infected patients (mean age 37 years, 54 male).Results:
Mean CD4 cell count and viral load was 200 cells/ml and 142,840 RNA copies/ml respectively. Ten mutations were identified V179D, L10I/V, M361, L63P, A71T/V, Y115F, V118I and K20R. None of these mutations is associated to a high degree of resistance to reverse transcriptase inhibitors, nucleoside analogs (NRTI), non nucleoside analogs (NNRTI) or viral protease inhibitors.Conclusions:
This is a first approach to study antiretroviral resistance in Chilean patients. This study must be amplified, since the prevalence of resistance may experience changes with time.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
HIV Infections
/
HIV-1
/
Antiretroviral Therapy, Highly Active
Type of study:
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2005
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital San José/CL
/
Universidad de Chile/CL
Similar
MEDLINE
...
LILACS
LIS