Peripheral nerve regeneration through the nerve tubulization technique
Braz. j. morphol. sci
;
21(4): 225-231, Oct. 2004. ilus
Article
in English
| LILACS
| ID: lil-406380
RESUMO
Transection of peripheral nerve results in a loss of function at the target organ that can rarely be recovered without surgical repais. Such an intervention usualy involves nerve autografting but is complicated by problems such as the need for secondary surgery, a limited donor nerve supply and loss of sensitivity in the donor nerve area. An alternative approach involving repair by nerve tubulization has been extensively used to study substances that may improve the regenerative process. An interesting feature of the tubulization technique is the possibility of filling the tube with substances that can enhance regeneration. Such substances include collagen, laminin, hyaluronic acid, fibronectin and more recently, glycosaminoglycans alone or with collagen. Biopolymers, purified glial cells, and neurothophic factors have also been tested. By using the tubulation technique, it has been possible to increase the number of regenerating fibers and the gap between the stumps. In this review, we discuss some of the basic concepts of this technique, as well as recent advances in this field.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Proteoglycans
/
Collagen
/
Laminin
/
Extracellular Matrix
/
Glycosaminoglycans
/
Nerve Growth Factors
/
Nerve Regeneration
Language:
English
Journal:
Braz. j. morphol. sci
Journal subject:
Anatomy
Year:
2004
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
State University of Campinas/BR
Similar
MEDLINE
...
LILACS
LIS