The prima donna of epigenetics: the regulation of gene expression by DNA methylation

Santos, K. F; Mazzola, T. N; Carvalho, H. F

Santos, K. F; Mazzola, T. N; Carvalho, H. F.

Santos, K. F; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia Celular. Campinas. BR
Mazzola, T. N; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia Celular. Campinas. BR
Carvalho, H. F; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia Celular. Campinas. BR

Braz. j. med. biol. res ; 38(10): 1531-1541, Oct. 2005.

Article in English | LILACS | ID: lil-409269

RESUMO

RESUMO

This review focuses on the mechanisms of DNA methylation, DNA methylation pattern formation and their involvement in gene regulation. Association of DNA methylation with imprinting, embryonic development and human diseases is discussed. Furthermore, besides considering changes in DNA methylation as mechanisms of disease, the role of epigenetics in general and DNA methylation in particular in transgenerational carcinogenesis, in memory formation and behavior establishment are brought about as mechanisms based on the cellular memory of gene expression patterns.

Subject(s)

Animals; Humans; DNA Methylation; Epigenesis, Genetic/genetics; Gene Silencing/physiology; Inheritance Patterns/genetics; Neoplasms/genetics; Cell Differentiation/genetics; CpG Islands/genetics; Epigenesis, Genetic/physiology; Gene Expression Regulation; Inheritance Patterns/physiology; Memory

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Full text: Available Index: LILACS (Americas) Main subject: DNA Methylation / Gene Silencing / Inheritance Patterns / Epigenesis, Genetic / Neoplasms Limits: Animals / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2005 Type: Article / Congress and conference Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR

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