Uso clínico de los nuevos antidepresivos que poseen un mecanismo de acción dual (revisión de la literatura) / Clinical use of new antidepressive agents with dual action (literature review)
Rev. méd. Panamá
;
25: 24-29, 2000.
Article
in Spanish
| LILACS
| ID: lil-409784
RESUMO
The effective pharmacological treatment of depression started in 1958 with the introduction of iproniazide and imipramine. New agents quickly followed with more specific actions and a safer side effect profile. Very recently, fourth generation antidepressants with dual action have been introduced. These new agents pose a challenging dilemma. Is it better to develop drugs ever more selective towards specific monoamine receptor subpopulations, or drugs that act upon several monoamines in a more focused way? The priority seems to be the investigation of the interactions of the various monoaminergic systems. This paper reviews the clinical use of the new antidepressants that implement the notion of dual action as an important element for efficacy combined with receptor-specific action as a basis for tolerability.
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Index:
LILACS (Americas)
Main subject:
Depressive Disorder
/
Antidepressive Agents
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Panamá
Journal subject:
Medicine
Year:
2000
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Universidad de Illinois/US
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