Linfoma/leucemia de células T del adulto (LLTA) secundario a HTLV-I: informe de un caso / T-cell lymphoma/leukemia secondary to HTLV-1 in adults: report of a case
Rev. méd. Panamá
;
23(1): 41-46, Jan.-May 1998.
Article
in Spanish
| LILACS
| ID: lil-409821
RESUMO
The Human T-Cell lymphotropic virus type I (HTLV-I) is endemic in the Caribbean basin, Japan, Central Africa and South Pacific. It as been associated to Lymphoma-Leukemia of Adult T-Cells (ATLL) and a progressive spastic paraparesis (TSP/HAM). The nationwide seroprevalence of Panama is of 1-2%. We report a case of a 73 year old male, albino, single, patient, Panamanian descendent from Jamaican immigrants who presented a skin disorder which started 1 year ago, characterized by the appearance of infiltrative, intensely pruritic papules, nodules and a non exfoliative erythroderna involving face, neck, trunk and extremities. He also had painless enlarged cervical lymph nodes, non tender hepatomegaly. Laboratory studies revealed a keukocyte count of 128,000/ml wit 67% atypical lymphocytes, serum calcium was 12.5 mg/dl, DL in 583 UNI, [quot ]flower cells[quot ] and atypical lymphocytes with hyperlobulated nuclear contour was observed in the peripheral blood smear, seropositivity to TLV-I detected by enzyme-linked immunosorbent assay (Elisa) and confirmed by Western blot assay. The skin biopsy shows a bandlike dermal infiltrates of atypical lymphoid cells with epidermotropism and Pautrier's microabscesses. Once the treatment was initiated with prednisone, cyclophosphamide, and systemic antibiotics for a bronchopneumonic process most of the cutaneous lesions cleared up although the clinical condition of our patient became progressively worse and died after a acute renal failure and a lower gastrointestinal bleeding. In 1986, the tree first cases of ATLL were identified in Panama, there has not been apparently new cases reported until now
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Index:
LILACS (Americas)
Main subject:
Skin Neoplasms
/
Leukemia-Lymphoma, Adult T-Cell
Limits:
Aged
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Panamá
Journal subject:
Medicine
Year:
1998
Type:
Article
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