Comparative analysis of noncoding sequences of orthologous bovine and human gene pairs
Genet. mol. res. (Online)
;
3(4): 465-473, 2004. tab, graf
Article
in English
| LILACS
| ID: lil-410891
ABSTRACT
Genomic sequence comparison across species has enabled the elucidation of important coding and regulatory sequences encoded within DNA. Of particular interest are the noncoding regulatory sequences, which influence gene transcriptional and posttranscriptional processes. A phylogenetic footprinting strategy was employed to identify noncoding conservation patterns of 39 human and bovine orthologous genes. Seventy-three conserved noncoding sequences were identified that shared greater than 70% identity over at least 100 bp. Thirteen of these conserved sequences were also identified in the mouse genome. Evolutionary conservation of noncoding sequences across diverse species may have functional significance, and these conserved sequences may be good candidates for regulatory elements.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Sequence Alignment
/
Sequence Analysis, DNA
/
Conserved Sequence
Limits:
Animals
/
Humans
Language:
English
Journal:
Genet. mol. res. (Online)
Journal subject:
Molecular Biology
/
Genetics
Year:
2004
Type:
Article
/
Project document
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Universidade Estadual Paulista/BR
/
University of Texas/US
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