Splicing factors are differentially expressed in tumors
Genet. mol. res. (Online)
;
3(4): 512-520, 2004. ilus, tab
Article
in English
| LILACS
| ID: lil-410895
RESUMO
Although alternative splicing of many genes has been found associated with different stages of tumorigenesis and splicing variants have been characterized as tumor markers, it is still not known whether these examples are sporadic or whether there is a broader association between the two phenomena. In this report we evaluated, through a bioinformatics approach, the expression of splicing factors in both normal and tumor tissues. This was possible by integrating data produced by proteomics, serial analysis of gene expression (SAGE) and microarray experiments. We observed a significant shift in the expression of splicing factors in tumors in both SAGE and microarray data, resulting from a large amount of experiments. We discuss that this supports the notion of a broader association between alternative splicing and cell transformation, and that splicing factors may be involved in oncogenic pathways.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Gene Expression Regulation, Neoplastic
/
Alternative Splicing
/
Neoplasms
Limits:
Humans
Language:
English
Journal:
Genet. mol. res. (Online)
Journal subject:
Molecular Biology
/
Genetics
Year:
2004
Type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
John Hopkins Universit/US
/
Ludwig Institute for Cancer Research/BR
Similar
MEDLINE
...
LILACS
LIS