A novel human G protein-coupled receptor is over-expressed in prostate cancer
Genet. mol. res. (Online)
;
3(4): 521-531, 2004. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-410896
RESUMO
G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the identification of a novel GPCR that shows no significant amino acid identity to any one of the known members of the GPCR superfamily. The gene expression pattern of this receptor is restricted: in normal tissues it is confined to the nervous system and testis, but we also detected gene expression in several tumor types, most notably prostate cancer, suggesting a potential role for this gene as a marker for this disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Prostatic Neoplasms
/
Gene Expression Regulation, Neoplastic
/
Receptors, G-Protein-Coupled
Limits:
Humans
/
Male
Language:
English
Journal:
Genet. mol. res. (Online)
Journal subject:
Molecular Biology
/
Genetics
Year:
2004
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Ludwig Institute for Cancer Research/BR
/
Universidade de São Paulo/BR
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