Evaluation of five screening tests licensed in Argentina for detection of hepatitis C virus antibodies
Mem. Inst. Oswaldo Cruz
;
100(3): 303-307, May 2005. tab
Article
in English
| LILACS
| ID: lil-411029
ABSTRACT
This study was conducted to compare among the most recent generation of five screening tests licensed in Argentina, in order to evaluate which of the tests has the best sensitivity for detection of antibodies against hepatitis C virus (HCV). The tests analyzed were Detect-HCV (3.0) Biochem ImmunoSystems, Canada; Hepatitis C EIA Wiener Lab., Argentina; Equipar HCV Ab, Italy; Murex HCV 4.0, UK and Serodia-HCV particles agglutination test, Japan. The results obtained showed high discrepancy between the different kits used and show that some of the tests assessed have a low sensitivity for anti-HCV detection in both chronic infections and early seroconversion, and indicate that among the commercially available kits in Argentina, Murex HCV 4.0 (UK) and Serodia-HCV particles agglutination test (Japan) have the best sensitivity for HCV screening. Although the sensitivity of the assays is the first parameter to be considered for blood screening, more studies should be carried out to assess the specificity of such assays.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Reagent Kits, Diagnostic
/
Hepatitis C
/
Hepacivirus
/
Hepatitis C Antibodies
Type of study:
Diagnostic study
/
Evaluation studies
/
Screening study
Limits:
Humans
Country/Region as subject:
South America
/
Argentina
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2005
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
1Facultad de Ciencias Medicas/AR
/
Facultad de Ciencias Medicas/AR
/
Universidad Católica de Córdoba/AR
/
Universidad Nacional de Córdoba/AR
Similar
MEDLINE
...
LILACS
LIS