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Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
Kaneshima, Edilson N; Castro-Prado, Marialba A. Alves de.
  • Kaneshima, Edilson N; Universidade Estadual de Maringá. Departamento de Análises Clínicas. Maringá. BR
  • Castro-Prado, Marialba A. Alves de; Universidade Estadual de Maringá. Departamento de Biologia Celular e Genética. Maringá. BR
Mem. Inst. Oswaldo Cruz ; 100(3): 325-330, May 2005. ilus, tab
Article in English | LILACS | ID: lil-411033
ABSTRACT
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 æM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.
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Full text: Available Index: LILACS (Americas) Main subject: Aspergillus nidulans / Diploidy / Mutagens / Nitroimidazoles Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Maringá/BR

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Full text: Available Index: LILACS (Americas) Main subject: Aspergillus nidulans / Diploidy / Mutagens / Nitroimidazoles Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Maringá/BR