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Resorbable extracellular matrix grafts in urologic reconstruction
Santucci, Richard A; Barber, Theodore D.
  • Santucci, Richard A; Wayne State University School of Medicine. Detroit. US
  • Barber, Theodore D; Wayne State University School of Medicine. Detroit. US
Int. braz. j. urol ; 31(3): 192-203, May-June 2005. ilus
Article in English | LILACS | ID: lil-411093
RESUMO

PURPOSE:

There is an increasingly large body of literature concerning tissue-engineering products that may be used in urology. Some of these are quite complex (such as multilayer patient-specific cell-seeded implants) yet the most simple and successful products to date are also the most uncomplicated resorbable acellular extra-cellular matrices (ECMs) harvested from animals. ECMs have been used in a variety of difficult urologic reconstruction problems, and this review is intended to summarize this complex literature for the practicing urologist.

METHODS:

Medline search of related terms such as "SIS, small intestinal submucosa, ECM, extracellular matrix, acellular matrix and urologic reconstruction". Manuscripts missed in the initial search were taken from the bibliographies of the primary references.

RESULTS:

Full review of potential clinical uses of resorbable extra-cellular matrices in urologic reconstruction.

CONCLUSIONS:

Currently, the "state of the art" in tissue engineering solutions for urologic reconstruction means resorbable acellular xenograft matrices. They show promise when used as a pubovaginal sling or extra bolstering layers in ureteral or urethral repairs, although recent problems with inflammation following 8-ply pubovaginal sling use and failures after 1- and 4-ply SIS repair of Peyronie's disease underscore the need for research before wide adoption. Preliminary data is mixed concerning the potential for ECM urethral patch graft, and more data is needed before extended uses such as bladder augmentation and ureteral replacement are contemplated. The distant future of ECMs in urology likely will include cell-seeded grafts with the eventual hope of producing "off the shelf" replacement materials. Until that day arrives, ECMs only fulfill some of the requirements for the reconstructive urologist.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Urologic Surgical Procedures / Urologic Diseases / Tissue Engineering / Extracellular Matrix / Intestinal Mucosa Limits: Animals / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2005 Type: Article Affiliation country: United States Institution/Affiliation country: Wayne State University School of Medicine/US

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Full text: Available Index: LILACS (Americas) Main subject: Urologic Surgical Procedures / Urologic Diseases / Tissue Engineering / Extracellular Matrix / Intestinal Mucosa Limits: Animals / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2005 Type: Article Affiliation country: United States Institution/Affiliation country: Wayne State University School of Medicine/US