Excellent response to interferon therapy in a patient with hypereosinophilic syndrome and elevated serum immunoglobulin E levels
Bol. Asoc. Méd. P. R
;
92(4/8): 59-62, Apr.-Aug. 2000.
Article
in English
| LILACS
| ID: lil-411272
ABSTRACT
The hypereosinophilic syndrome (HES) is a heterogeneous disease characterized by sustained eosinophilia for a period of at least six months with evidence of organ involvement. Its manifestations range from a benign disorder not requiring any therapy to an aggressive, malignant variety refractory to common treatments. Diverse therapies have been used, including steroids, hydroxyurea, and chemotherapy, with variable responses. Recently alpha-interferon therapy has been shown effective in this disorder. Of the various prognostic factors, elevated serum immunoglobulin E (IgE) levels is considered among the most favorable, with most patients presenting with a [quot ]benign[quot ] disorder, not requiring therapy. We describe a patient presenting with an aggressive variant of HES despite having elevated IgE levels. The patient had a dramatic and lasting response to alpha-interferon
Search on Google
Index:
LILACS (Americas)
Main subject:
Interferon-alpha
/
Hypereosinophilic Syndrome
/
Antineoplastic Agents
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Bol. Asoc. Méd. P. R
Journal subject:
Medicine
Year:
2000
Type:
Article
Affiliation country:
Puerto Rico
Institution/Affiliation country:
University of Puerto Rico/PR
Similar
MEDLINE
...
LILACS
LIS