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Hypodontia: genetics and future perspectives
Pemberton, Trevor J; Das, Parimal; Patel, Pragna I.
  • Pemberton, Trevor J; Institute of Genetic Medicine. US
  • Das, Parimal; University of Southern California. US
  • Patel, Pragna I; Anderson Cancer Center. Houston. US
Braz. j. oral sci ; 4(13): 695-706, Apr.-June 2005. ilus, tab
Article in English | LILACS, BBO | ID: lil-412547
RESUMO
Tooth development is a complex process of reciprocal interactions that we have only recently begun to understand. With the large number of genes involved in the odontogenic process, the opportunity for mutations to disrupt this process is high. Tooth agenesis (hypodontia)is the most common craniofacial malformation with patients missing anywhere from one tooth to their entire dentition. Hypodontia can occur in association with other developmental anomalies (syndromic) or as an isolated condition (non-syndromic). Recent advances in genetictechniques have allowed us to begin understanding the genetic processes that underlie the odontogenic process and to identify the mechanisms responsible for tooth agenesis. Thus far two genes have been identifiedby mutational analysis as the major causes of non-syndromic hypodontia; PAX9 and MSX1. Haploinsufficiency of either has been observed to cause the more severe forms of hypodontia whilst point mutations cause hypodontia to varying degrees of severity. With theprevalence of hypodontia having been observed to have increased during the 20th century, the future identification and analysis of its geneticbasis is essential to allow us to better treat the condition. The clinician can facilitate this process by collaborating with the human geneticist and referring patients/families with familial hypodontia for investigative research
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Index: LILACS (Americas) Main subject: Anodontia Type of study: Prevalence study / Risk factors Language: English Journal: Braz. j. oral sci Journal subject: Dentistry Year: 2005 Type: Article Affiliation country: United States Institution/Affiliation country: Anderson Cancer Center/US / Institute of Genetic Medicine/US / University of Southern California/US

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Index: LILACS (Americas) Main subject: Anodontia Type of study: Prevalence study / Risk factors Language: English Journal: Braz. j. oral sci Journal subject: Dentistry Year: 2005 Type: Article Affiliation country: United States Institution/Affiliation country: Anderson Cancer Center/US / Institute of Genetic Medicine/US / University of Southern California/US