Pathological extension of prostate cancer as defined by gleason score on biopsy
Int. braz. j. urol
;
31(4): 326-330, July-Aug. 2005. tab
Article
in English
| LILACS
| ID: lil-412890
RESUMO
INTRODUCTION:
Based on the importance of the Gleason score on the behavior of prostate adenocarcinoma, this study attempts to predict the extension of prostate adenocarcinoma pre-operatively, as defined by the Gleason score on biopsy, in individuals who will undergo radical prostatectomy. MATERIALS ANDMETHODS:
We selected 899 individuals who underwent retropubic radical prostatectomy from 1988 to 2004. Clinical and pathological data obtained in the preoperative period were retrospectively analyzed through digital rectal examinations of the prostate, initial serum PSA levels and pathological data provided by biopsy. The Gleason score on biopsy was assessed and divided into 3 groups 2 to 6, 7, and 8 to 10, and correlated with the possibility of the disease being confined to the prostate.RESULTS:
From the 899 selected patients, 654 (74 percent) showed Gleason scores of 2 to 6, 165 (18 percent) had a score of 7 and 80 (9 percent) had scores of 8 to 10 on biopsy. The likelihood of confined diseases, extraprostatic extensions, invasion of seminal vesicles and lymph nodal involvement were respectively 74 percent, 18 percent, 8 percent and 0.8 percent for a Gleason score of 2 to 6, 47 percent, 30 percent, 19 percent and 4 percent for a Gleason score of 7, and 49 percent, 29 percent, 18 percent and 4 percent for a Gleason score of 8 to 10.CONCLUSION:
In patients who will undergo radical prostatectomy due to prostate adenocarcinoma, a Gleason score of 7 on biopsy shows the same behavior as a Gleason score of 8 to 10 in relation to extension of disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Prostatic Neoplasms
/
Adenocarcinoma
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2005
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Sao Paulo/BR
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