Effects of manganese ions in the neuromuscular junction
Rev. bras. toxicol
;
v.18(1): 17-26, jul. 2005. ilus, graf
Article
in English
| LILACS
| ID: lil-417095
RESUMO
The neurotoxic effects of manganese occured mainly from its inhalation are well described in the literature. In this study we have been demonstrated the potent and reversible effect of manganese ions (Mn²+) on neuromuscular transmission using conventional myographic. The Mn²+ mechanism wich causes reversible blockade at neuromuscular junction was investigated in isolated mouse phrenic nerve-diaphragm (PND) preparations. As much Mn²+ 0.9 mM as Mn²+ 1.8 mM produced rapid neuromuscular blockade (50% in < 4 min), but only the lower concentration reversed spontaneously. The use of d-tubocurarine (5.8 µM), 3,4-diaminopyridine 3,4-DAP, 0.09 mM) and dantrolene (10 µM) excluded the involvment of nicotinic receptors, K+ channels and ryanodine receptors, respectively, as the potential target for this ion. Manganese acts an early competitive antagonist and after as an agonist of Ca²+, indicating that this ion may probably act via Ca²+ cannels...
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Index:
LILACS (Americas)
Main subject:
Manganese Poisoning
/
Manganese
/
Neuromuscular Junction
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. bras. toxicol
Journal subject:
Toxicology
Year:
2005
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
State University of Campinas/BR
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