Frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenos / Frequency and characteristics of aspirin resistance in Chilean cardiovascular patients
Rev. méd. Chile
;
133(4): 409-417, abr. 2005. tab, graf
Article
in Spanish
| LILACS
| ID: lil-417378
RESUMO
Background:
Studies performed in Anglo-Saxon countries show that 5 percent of patients are resistant to the antiplatelet effects of aspirin.Aim:
To assess the prevalence of aspirin resistance in a sample of Chilean cardiovascular patients and its association with clinical and laboratory characteristics. Patients andMethods:
Ninety nine patients (30 women, 63n10 years) treated for stable cardiovascular diseases with aspirin 100-325 mg/day were studied. Clinical and basic coagulation variables were assessed. Platelet aggregation was studied with platelet rich plasma using three different agonists in an optical aggregometer. Aspirin resistance was defined as an aggregation >20 percent with arachidonic acid and an aggregation >70 percent with ADP or collagen.Results:
Eleven patients (11.11 percent, 95 percent CI= 4.95-17.27 percent) complied with both criteria and were classified as aspirin resistant. Current smoking was more common in aspirin resistant patients (63.6 vs 29.6 percent, p=0.039).Conclusions:
Aspirin resistance was found in a significant proportion of cardiovascular patients and was more common among current smokers.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cardiovascular Diseases
/
Aspirin
Type of study:
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2005
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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