Mecanismos moleculares en el daño por isquemia-reperfusión hepática y en el preacondicionamiento isquémico / Molecular mechanisms in liver ischemic-reperfusion injury and ischemic preconditioning
Rev. méd. Chile
;
133(4): 469-476, abr. 2005. ilus
Article
in Spanish
| LILACS
| ID: lil-417387
RESUMO
Ischemia-reperfusion (IR) liver injury is associated with temporary clamping of hepatoduodenal ligament during liver surgery, hypoperfusion shock and graft failure after liver transplantation. Mechanisms of IR liver injury include i) loss of calcium homeostasis, ii) reactive oxygen and nitrogen species generation, iii) changes in microcirculation, iv) Kupffer cell activation, and (v) complement activation. Pre-exposure of the liver to transient ischemia increases the tolerance to IR injury, a phenomenon known as hepatic ischemic preconditioning (IP). IP involves i) recovery of the energy supply and calcium, sodium and pH homeostasis, ii) enhancement in the antioxidant potential, and iii) expression of multiple stress-response proteins, including acute phase proteins, heat shock proteins, and heme oxygenase. These observations and preliminary studies in humans give a rationale for the assessment of IP in minimizing or preventing IR injury during surgery and non surgical conditions of tissue hypoperfusion.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Ischemic Preconditioning
/
Liver
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2005
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Hospital del Salvador/CL
/
Universidad de Chile/CL
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