Association between diabetes type 1 and DQB1 alleles in a case-control study conducted in Montevideo, Uruguay
Genet. mol. res. (Online)
;
2(1): 29-35, Mar. 2003.
Article
in English
| LILACS
| ID: lil-417627
RESUMO
We studied HLA DQB1 allele frequencies and the relative risk (RR) of various genotypes in 72 type 1 diabetic patients and 40 control individuals in Uruguay. This is a tri-racial (Caucasian, Black and Indo-American) mixed population. The products of the polymerase chain reaction amplifications were hybridized with oligonucleotides by allele-specific oligonucleotide reverse or dot blot methods. Significant differences between these two groups were observed only for allele DQB1*0302 (35, RR = 7.34, P<0.001). The frequency of the alleles carrying a non-aspartic acid residue at position 57 was significantly higher in the diabetic patients (85 vs 53, P<0.001). In contrast, the frequency of Asp alleles was negatively associated with type 1 diabetes (RR = 0.20, P<0.001). The genotype DQB1*0302/DQB1*0201 (33, RR = 5.41, P<0.05) was positively associated with this disease. The genotype frequencies associated with type 1 diabetes in our population were significantly different from what is known for Caucasian and Black populations as well as compared with another admixed population, from Chile
Full text:
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Index:
LILACS (Americas)
Main subject:
HLA-DQ Antigens
/
Genetic Predisposition to Disease
/
Diabetes Mellitus, Type 1
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Uruguay
Language:
English
Journal:
Genet. mol. res. (Online)
Journal subject:
Molecular Biology
/
Genetics
Year:
2003
Type:
Article
Affiliation country:
Uruguay
Institution/Affiliation country:
University of the Republic/UY
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