In vitro release of propolis from gelatin microparticles prepared by spray-drying technique
Rev. ciênc. farm
;
25(2): 79-84, 2004. ilus
Article
in English
| LILACS
| ID: lil-418895
ABSTRACT
The purpose of this study was to investigative the in vitro release of propolis from gelatin microparticles. Gelatin microparticles containing porpolis extractive solution (PES) were prepared by spray-drying technique. Microparticles with a mean diameter of 2.50 µm and with regular morphology were obtained. The entrapment efficiency of propolis in the microparticles was over 39%. Spray-drying showed to be a feasible method for the preparation of gelatin microparticles containing propolis. Comparing to PES, the in vitro release of propolis from gelatin microparticles in aqueous medium was slower, considering markes 1 and 2. Thus, it was possible to transform a liquid propolis dosage form into a solid one, improving manipulation, packaging and storage and with modified release in aqueous medium, comparatively to the ethanolic extract of the drug
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Index:
LILACS (Americas)
Main subject:
Propolis
/
In Vitro Techniques
/
Drug Compounding
/
Gelatin
Language:
English
Journal:
Rev. ciênc. farm
Journal subject:
Pharmacology
Year:
2004
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual Paulista/BR
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