In vitro activity of tigecycline, a new glycylcycline, tested against 1,326 clinical bacterial strains isolated from Latin America
Braz. j. infect. dis
;
9(5): 348-356, Oct. 2005. tab
Article
in English
| LILACS
| ID: lil-419643
RESUMO
The in vitro activity of tigecycline (former GAR-936), a new semisynthetic tetracycline, was evaluated in comparison with tetracycline and other antimicrobial agents. MATERIAL AND METHODS: A total of 1,326 contemporary clinical isolates collected from the Latin American region were collected in 2000-2002 period and tested with microdilution broth according to the CLSI guidelines. The bacterial pathogens evaluated included Staphylococcus aureus (505), Streptococcus pneumoniae (269), coagulase-negative staphylococci (CoNS; 227), Haemophilus influenzae (129), Enterococcus spp. (80), Moraxella catarrhalis (54), beta-haemolytic streptococci (28), viridans group streptococci (26), and Neisseria meningitidis (8) RESULTS:Tigecycline demonstrated excellent activity against all Gram-positive cocci, with 90 percent of penicillin-resistant S. pneumoniae strains being inhibited at 0.12 æg/mL, while the same isolates had an MIC90 of > 16 æg/mL for tetracycline. All Enterococcus spp. were inhibited at 0.25 æg/mL of tigecycline. Tigecycline (MIC50, 0.25 æg/mL) was eight-fold more potent than minocycline (MIC50, 2 æg/mL) against oxacillin-resistant S. aureus (ORSA); all ORSA were inhibited at < 2 æg/mL of tigecycline. Tigecycline demonstrated excellent activity (MIC50, 0.5 æg/mL) against CoNS with reduced susceptibility to teicoplanin (MIC, 16 æg/mL). Tigecycline also showed high potency against respiratory pathogens such as M. catarrhalis (MIC50, 0.12 æg/mL) and H. influenzae (MIC50, 0.5 æg/mL). No tigecycline resistant isolates were detected when the proposed susceptible breakpoints (< 4 æg/mL) was applied. CONCLUSIONS: This results indicate that tigecycline has potent in vitro activity against clinically important pathogenic bacteria, including Gram-positive isolates resistant to both tetracycline and minocycline.
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Index:
LILACS (Americas)
Main subject:
Tetracycline
/
Drug Resistance, Bacterial
/
Gram-Negative Bacteria
/
Gram-Positive Bacteria
/
Minocycline
/
Anti-Bacterial Agents
Type of study:
Controlled clinical trial
/
Practice guideline
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2005
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Department of Medicine/BR
/
Federal University of São Paulo/BR
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