Susceptibility of Streptococcus pneumoniae to penicillin in the state of Minas Gerais, Brazil from 1997-2004
Braz. j. infect. dis
;
9(5): 390-397, Oct. 2005. tab
Article
in English
| LILACS
| ID: lil-419648
RESUMO
We monitored the susceptibility to penicillin of invasive strains of Streptococcus pneumoniae in two reference laboratories; 502 positive cultures from patients with an active invasive infectious process were analyzed. Streptococcus pneumoniae was identified through conventional procedures, and the oxacillin disc diffusion method was used to check for penicillin susceptibility. Statistical analysis included calculations of the frequency distribution, with 95 percent confidence intervals (CI), as well as chi-square tests and chi-square for linear trend for temporal analysis of susceptibility. The bacterium was isolated from patients less than a year old (40.7 percent of the isolates), from infants (55.9 percent), and from individuals less than 15 years old (64.4 percent). The majority (88.2 percent, 95 percent CI = 85.5 percent-91.1 percent) of the 502 isolates were susceptible to penicillin. There was no significant temporal trend of elevation of resistance rate during the study period (p=0.56). We conclude that resistance of S. pneumoniae to penicillin is not yet an important clinical-epidemiological concern in the State of Minas Gerais. To provide necessary support for the adoption of therapeutic and prophylactic measures, epidemiological surveillance should be implemented at a national level to monitor the profile of susceptibility/resistance of S. pneumoniae to penicillin and other antimicrobials.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Oxacillin
/
Pneumococcal Infections
/
Streptococcus pneumoniae
/
Penicillin Resistance
/
Anti-Bacterial Agents
Type of study:
Controlled clinical trial
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2005
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Minas Gerais/BR
/
State Secretary of Health of Minas Gerais/BR
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