Ticks, ivermectin, and experimental Chagas disease
Mem. Inst. Oswaldo Cruz
;
100(8): 829-832, Dec. 2005. tab
Article
in English
| LILACS
| ID: lil-419947
ABSTRACT
Following an infestation of dogticks in kennels housing dogs used for long-term studies of the pathogenesis of Chagas disease, we examined the effect of ivermectin treatment on the dogs, ticks, trypanosome parasites, and also on triatomine vectors of Chagas disease. Ivermectin treatment was highly effective in eliminating the ticks, but showed no apparent effect on the dogs nor on their trypanosome infection. Triatominae fed on the dogs soon after ivermectin treatment showed high mortality, but this effect quickly declined for bugs fed at successive intervals after treatment. In conclusion, although ivermectin treatment may have a transient effect on peridomestic populations of Triatominae, it is not the treatment of choice for this situation. The study also showed that although the dogticks could become infected with Trypanosoma cruzi, this only occurred when feeding on dogs in the acute phase of infection, and there was no evidence of subsequent parasite development in the ticks.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tick Infestations
/
Trypanosoma cruzi
/
Ivermectin
/
Chagas Disease
/
Rhipicephalus sanguineus
/
Dog Diseases
/
Antiparasitic Agents
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2005
Type:
Article
Affiliation country:
Brazil
/
United kingdom
Institution/Affiliation country:
Fiocruz/BR
/
London School of Hygiene and Tropical Medicine/GB
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