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Clinical and pathological importance of vacA allele heterogeneity and cagA status in peptic ulcer disease in patients from north Brazil
Martins, Luisa Caricio; Corvelo, Tereza Cristina de Oliveira; Demachki, Samia; Araujo, Marialva Tf; Assumpção, Mônica Baraúna; Vilar, Simone Cristina Araujo Jucá; Freitas, Felipe Bonfim; Barbosa, Hivana Patricia Melo; Fecury, Amanda Alves; Amaral, Renata Kelly Costa do; Santos, Sidney Emanuel Batista dos.
  • Martins, Luisa Caricio; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Genética. Laboratório de Imunogenética. Belém. BR
  • Corvelo, Tereza Cristina de Oliveira; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Genética. Laboratório de Imunogenética. Belém. BR
  • Demachki, Samia; Hospital Universitário João de Barros Barreto. Departamento de Patologia. Belém. BR
  • Araujo, Marialva Tf; Hospital Universitário João de Barros Barreto. Departamento de Patologia. Belém. BR
  • Assumpção, Mônica Baraúna; Hospital Universitário João de Barros Barreto. Departamento de Endoscopia. Belém. BR
  • Vilar, Simone Cristina Araujo Jucá; Hospital Ofir Loiola. Departamento de Endoscopia. Belém. BR
  • Freitas, Felipe Bonfim; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Genética. Laboratório de Imunogenética. Belém. BR
  • Barbosa, Hivana Patricia Melo; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Genética. Laboratório de Imunogenética. Belém. BR
  • Fecury, Amanda Alves; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Genética. Laboratório de Imunogenética. Belém. BR
  • Amaral, Renata Kelly Costa do; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Genética. Laboratório de Imunogenética. Belém. BR
  • Santos, Sidney Emanuel Batista dos; Universidade Federal do Pará. Departamento de Patologia. Laboratório de Genética Humana e Médica. Belém. BR
Mem. Inst. Oswaldo Cruz ; 100(8): 875-881, Dec. 2005. tab
Article in English | LILACS | ID: lil-419954
ABSTRACT
We have examined the prevalence of gene cagA and vacA alleles in 129 patients, 69 with gastritis and 60 with peptic ulcer diseases from North Brazil and their relation with histopathological data. vacA and cagA genotype were determined by polymerase chain reaction. Hematoxylin-eosin staining was used for histological diagnosis. 96.6 percent of the patients were colonized by Helicobacter pylori strains harboring single vacA genotype (nont-mixed infection). Among them, 11.8 percent had subtype s1a, 67.8 percent had subtype s1b, and 17 percent subtype s2. In regard to the middle region analysis, m1 alleles were found in 75.4 percent and m2 in 21.2 percent of patients. The cagA gene was detected in 78 percent patients infected with H. pylori and was associated with the s1-m1 vacA genotype. The H. pylori strains, vacA s1b m1/cagA-positive, were associated with increased risk of peptic ulcer disease and higher amounts of lymphocytic and neutrophilic infiltrates and the presence of intestinal metaplasia. These findings show that cagA and vacA genotyping may have clinical relevance in Brazil.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Peptic Ulcer / Bacterial Proteins / Helicobacter pylori / Helicobacter Infections / Gastritis / Antigens, Bacterial Type of study: Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Ofir Loiola/BR / Hospital Universitário João de Barros Barreto/BR / Universidade Federal do Pará/BR

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Full text: Available Index: LILACS (Americas) Main subject: Peptic Ulcer / Bacterial Proteins / Helicobacter pylori / Helicobacter Infections / Gastritis / Antigens, Bacterial Type of study: Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Ofir Loiola/BR / Hospital Universitário João de Barros Barreto/BR / Universidade Federal do Pará/BR