Proteína Tax ( HTLV-I ), probable factor patogénico y marcador del síndrome sicca que se asocia a HAM/TSP / Viral Tax protein expression in salivary glands of patients infected with human t-cell lymphotropic virus type I and Sicca Syndrome
Rev. méd. Chile
;
133(10): 1183-1190, oct. 2005. ilus
Article
in Spanish
| LILACS
| ID: lil-420146
ABSTRACT
Background:
Human T-cell lymphotropic virus type I (HTLV-I) is a retrovirus that influences cellular metabolism modifying biological responses. This results in oncogenic, degenerative or inflammatory changes. The myelopathy associated to HTLV-I or tropical spastic paraparesia (HAM/TSP) is a mainly degenerative response to the virus infection. On the other hand, Sjögren syndrome has an inflammatory appearance. The immunohistochemical study of CD-4, CD-8 and CD45 lymphocytes, metalloproteinase MMP-9 and viral Tax protein in pathological samples of salivary glands may help to differentiate primary from viral Sicca syndrome.Aim:
To perform an immunohistochemical study of salivary glands of patients with HAM/TSP and Sicca syndrome and control subjects. Material andMethods:
Pathological samples of salivary glands from 53 patients with HAM/TSP and Sicca syndrome and 10 control subjects, were studied. Immunohistochemistry was performed using antibodies against CD-4, CD-8 and CD-45 lymphocytes, metalloproteinase MMP-9 and viral Tax protein.Results:
Only in patients with HAM/TSP and Sicca syndrome, the presence of Tax protein was observed in CD-4 and CD-8 lymphocytes and in glandular acini.Conclusions:
Patients infected with HTLV-I express Tax protein in salivary glands. This finding has diagnostic and pathogenic implications.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Salivary Glands
/
Human T-lymphotropic virus 1
/
Leukemia-Lymphoma, Adult T-Cell
/
Sjogren's Syndrome
/
Gene Products, tax
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2005
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Instituto de Salud Pública/CL
/
Universidad de Chile/CL
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